Brown adipose tissue transplantation ameliorates polycystic ovary syndrome.

نویسندگان

  • Xiaoxue Yuan
  • Tao Hu
  • Han Zhao
  • Yuanyuan Huang
  • Rongcai Ye
  • Jun Lin
  • Chuanhai Zhang
  • Hanlin Zhang
  • Gang Wei
  • Huiqiao Zhou
  • Meng Dong
  • Jun Zhao
  • Haibin Wang
  • Qingsong Liu
  • Hyuek Jong Lee
  • Wanzhu Jin
  • Zi-Jiang Chen
چکیده

Polycystic ovary syndrome (PCOS), which is characterized by anovulation, hyperandrogenism, and polycystic ovaries, is a complex endocrinopathy. Because the cause of PCOS at the molecular level is largely unknown, there is no cure or specific treatment for PCOS. Here, we show that transplantation of brown adipose tissue (BAT) reversed anovulation, hyperandrogenism, and polycystic ovaries in a dehydroepiandrosterone (DHEA)-induced PCOS rat. BAT transplantation into a PCOS rat significantly stabilized menstrual irregularity and improved systemic insulin sensitivity up to a normal level, which was not shown in a sham-operated or muscle-transplanted PCOS rat. Moreover, BAT transplantation, not sham operation or muscle transplantation, surprisingly improved fertility in PCOS rats. Interestingly, BAT transplantation activated endogenous BAT and thereby increased the circulating level of adiponectin, which plays a prominent role in whole-body energy metabolism and ovarian physiology. Consistent with BAT transplantation, administration of adiponectin protein dramatically rescued DHEA-induced PCOS phenotypes. These results highlight that endogenous BAT activity is closely related to the development of PCOS phenotypes and that BAT activation might be a promising therapeutic option for the treatment of PCOS.

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عنوان ژورنال:
  • Proceedings of the National Academy of Sciences of the United States of America

دوره 113 10  شماره 

صفحات  -

تاریخ انتشار 2016